- Obstetricians & Gynecologists, Weirton - Ob-Gyn Doctors, Physicians & Surgeons (Obstetrics & Gynecology)
- Office Supplies, Equipment & Office Furniture Stores, Weirton
- Oil & Gas Land Leases Properties & Royalties, Weirton
- Oil & Petroleum Products, Weirton - Merchant, Wholesalers, etc
- Oil Change & Lubrication, Weirton - Auto Oil & Quick Lube
- Ophthalmologists, Weirton - Eye Doctors, Physicians & Surgeons (Ophthalmology)
- Opticians, Weirton
- Optometrists, Weirton - Eye Doctors, Physicians & Surgeons (Optometry)
- Oral Surgeon, Weirton - Dentists - Oral & Maxillofacial Surgeons
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- Ornamental Nursery, Weirton
- Ornamental Nursery Services, Weirton
- Orthodontist, Weirton - Teeth Straightening, Invisalign & Dental Braces
- Orthodox Churches, Weirton
- Orthopedists, Weirton - Orthopedic Surgery Doctors, Physicians & Surgeons
- Other Building Materials & Supplies, Weirton
- Outdoor Furniture & Patio Furniture, Weirton - Garden Furniture Stores
- Oxygen & Respiratory Equipment & Supplies, Weirton - Oxygen Concentrator, Tank, Machine, etc
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