- Salvage Yards, Shepherdstown - Auto, Motorcycle, Boat, Trucks, etc
- Savings Banks, Shepherdstown
- Scrap & Waste Materials, Shepherdstown
- Secondary Schools, Shepherdstown
- Security Brokers & Dealers, Shepherdstown
- Service Establishment Supplies & Equipment, Shepherdstown
- Service Industry Manufacturers Machinery, Shepherdstown
- Sewage Treatment Plant Contractors, Shepherdstown
- Shoe Stores, Shepherdstown - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Shepherdstown
- Snacks & Desserts, Shepherdstown
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- Snow Removal Services, Shepherdstown - Snow Plow Service
- Soccer Clubs, Shepherdstown
- Social Services & Welfare, Shepherdstown
- Social Workers & Services, Shepherdstown
- Societies & Foundation Associations, Shepherdstown
- Special Interest Schools Or Instruction, Shepherdstown
- Specialty Stores, Shepherdstown
- Sprinkler Alarm Systems, Shepherdstown - Fire Sprinkler Systems
- Stocks & Bond Brokers, Shepherdstown
- Structural Engineer, Shepherdstown
- Surveyor Services, Shepherdstown - Surveying Service
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