- Salvation Army, Weirton
- Sand Gravel & Aggregate, Weirton
- Sandwich Shop Restaurants, Weirton
- Sanitation Consultants, Weirton
- Satellite & Cable TV Equipment & Systems, Weirton
- Savings & Loan Associations, Weirton
- Savings Banks, Weirton
- Scales Retail, Weirton
- Scientific Services, Weirton
- Scrap & Waste Machinery, Weirton
- Scrap & Waste Materials, Weirton
- Screen Printing, Weirton
- Seafood Restaurants, Weirton
- Sealcoating, Weirton - Asphalt Sealcoating & Paving
- Search & Rescue, Weirton
- Secondary Schools, Weirton
- Secretarial & Court Reporting Services, Weirton
- Security & Surveillance System & Equipment, Weirton
- Security Alarm Systems - Home & Business, Weirton
- Security Brokers & Dealers, Weirton
- Security Control Systems & Monitoring, Weirton - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Guard & Patrol Service, Weirton - Bodyguard, Guard Dogs, Etc
- Security Services, Weirton
- Sewer & Drain Cleaning & Repair, Weirton - Drain Cleaner & Installation Services
- Shirts & T-Shirts, Weirton
- Shopping & Shopping Services, Weirton
- Siding Contractors, Weirton - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Weirton
- Sleep Disorders Treatment & Information Centers, Weirton
- Small Appliances, Weirton
- Snacks & Desserts, Weirton
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- Social Clubs & Organizations, Weirton
- Social Services & Welfare, Weirton
- Societies & Foundation Associations, Weirton
- Sororities, Weirton
- Spare Rib Restaurants, Weirton
- Special Coatings, Weirton - Protective Coatings
- Special Education & Care, Weirton
- Special Interest Schools Or Instruction, Weirton
- Specialty Animal Services, Weirton
- Specialty Stores, Weirton
- Speech & Hearing Specialists, Weirton
- Sporting Goods Stores, Weirton
- Sports Bars & Lounges, Weirton
- Sports Medicine, Weirton - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, Weirton - Sports Clothes
- Stadiums, Arenas, Coliseums & Athletic Fields, Weirton
- Staffing & Support Services, Weirton
- Stamp Collecting & Coin Dealers , Weirton
- State Government, Weirton
- Steak House Restaurants, Weirton
- Steel Detailers, Weirton
- Steel Manufacturers, Weirton
- Steel Mills & Blast Furnaces, Weirton
- Steel Work Contractors, Weirton
- Stock & Bond Brokers & Dealers, Weirton
- Stocks & Bond Brokers, Weirton
- Store Fixtures & Display Equipment, Weirton
- Stoves & Furnace Equipment, Weirton - Fittings & Repair Parts
- Substance Abuse Clinics, Weirton - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Weirton - Surveying Service
- Swimming Pools, Weirton
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